Who Needs Carbs

managing an LCHF lifestyle in Israel

Insulin (III) – “The Bully”

There are many substances in the body that regulate fatty acid uptake and their release from the fat tissue when needed. Two who particularly influence are:

– The enzyme LPL (lipoprotein lipase) – It draws the fatty acids from the blood into cells. LPL is found on both the surface of muscle cells and the of fat cells. The fatty acid that is pumped into the muscle cells are used for energy and those fatty acids that are pumped into the fat cells are stored as triglycerides. (Triglyceride = a molecule with a glycerol “head” and three fatty acids “tails”.)

– The enzyme HSL (hormone sensitive lipase) – Resides inside the fat cells and breaks down the stored triglycerides into fatty acids. (Only fatty acids are small enough to pass through the cell membrane and thus return for use elsewhere.)

These two enzymes are very sensitive to the amount of insulin in the blood and are affected accordingly. The slightest raise of insulin causes the LPL on the fat cell surface to increase performance and suck up more fatty acids into the cell. Simultaneously insulin causes HSL to lower its function and not to break down triglycerides.

(Feb 20, 2011)

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This entry was posted on November 21, 2011 by in General and tagged , .

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